What is the Origin of Stress Mitigation Hormones?

This descriptive phrase originates from the need to identify hormones that actively oppose the systemic disruption caused by the classic stress response pathways. It separates the initiators of the stress response from the agents tasked with dampening the resulting metabolic and immunological changes. The focus is specifically on the return to a balanced physiological state.

What is the Mechanism of Stress Mitigation Hormones?

The mechanism involves several pathways, including the modulation of the hypothalamic-pituitary-adrenal (HPA) axis through negative feedback loops, often involving the action of neurosteroids like allopregnanolone or DHEA metabolites. These compounds can dampen excessive glucocorticoid receptor signaling or promote anti-inflammatory signaling cascades within immune cells. Ultimately, they facilitate the transition from a survival state back to a maintenance and repair state.

Stress Mitigation Hormones ∞ Area

Stress Mitigation Hormones

Meaning

Stress Mitigation Hormones are the endogenous compounds that actively work to resolve the physiological cascade initiated by acute or chronic allostatic load, aiming to restore systemic equilibrium or allostasis. While initial stress involves the rapid release of glucocorticoids, these mitigation hormones work to temper the catabolic effects and promote recovery pathways. They are essential for preventing the long-term detrimental impact of sustained HPA axis activation on tissues. Effective management of wellness relies on supporting these counter-regulatory signals.