What is the Origin of Stress Mediator Balance?

The concept arises from psychoneuroimmunology and clinical endocrinology, where the long-term consequences of allostatic load on hormonal axes were quantified. The ratio of cortisol to DHEA emerged as a superior metric to single-point measurements, reflecting the overall anabolic versus catabolic tone of the stress response. It is a cornerstone of assessing adrenal health.

What is the Mechanism of Stress Mediator Balance?

Cortisol, the primary glucocorticoid, mediates the catabolic phase of the stress response, mobilizing energy reserves and suppressing non-essential functions. DHEA, an adrenal androgen, acts as a counter-regulatory, anabolic, and neuroprotective hormone. Maintaining balance involves the precise negative feedback regulation of the HPA axis. A persistent imbalance, characterized by high cortisol and low DHEA, drives chronic inflammation, muscle atrophy, and impaired immune function.

Stress Mediator Balance ∞ Area

Stress Mediator Balance

Meaning

Stress Mediator Balance is the dynamic, homeostatic equilibrium between the body’s primary catabolic stress hormones and counter-regulatory systems, most notably the ratio of cortisol to DHEA (Dehydroepiandrosterone). This balance is a critical clinical indicator of the hypothalamic-pituitary-adrenal (HPA) axis function and an individual’s capacity to adapt effectively to chronic physiological and psychological demands. Optimal balance supports resilience and prevents systemic burnout.