What is the Origin of Stress Mediator Attenuation?

This descriptive term combines stress mediator, referring to the chemical signals of the stress response, with attenuation, meaning to reduce the force, effect, or value of something. The concept is central to psychoneuroendocrinology, focusing on the therapeutic target of normalizing the body's reaction to persistent environmental demands.

What is the Mechanism of Stress Mediator Attenuation?

Attenuation is achieved through negative feedback loops, primarily involving the hippocampus's inhibitory control over the hypothalamic-pituitary-adrenal (HPA) axis, leading to reduced cortisol secretion. Furthermore, it involves the activation of parasympathetic nervous system pathways that counterbalance sympathetic drive. Clinically, this process can be supported by interventions that enhance inhibitory neurotransmitter function and reduce the chronic expression of inflammatory signaling pathways.

Stress Mediator Attenuation ∞ Area

Stress Mediator Attenuation

Meaning

Stress mediator attenuation is the physiological process of reducing the intensity, duration, or downstream effects of chemical messengers released in response to acute or chronic stressors. These mediators include hormones like cortisol and catecholamines, as well as pro-inflammatory cytokines. Effective attenuation is vital for preventing the transition from adaptive stress response to maladaptive allostatic overload and subsequent systemic pathology.