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Stress-Induced Insulin Resistance

Meaning

Stress-Induced Insulin Resistance is a temporary or chronic state of impaired cellular responsiveness to insulin that is directly triggered by the sustained or acute physiological response to stress. The elevated levels of stress hormones, primarily cortisol and catecholamines, antagonize insulin action, leading to persistently high circulating glucose levels. This condition represents a survival mechanism where the body prioritizes glucose availability for the brain and muscles during a perceived threat. Clinically, chronic stress-induced resistance contributes significantly to metabolic syndrome and visceral fat accumulation.