What is the Origin of Stress-Induced Impairment?

The term is rooted in the concepts of stress physiology and allostasis, developed by Hans Selye and Bruce McEwen, respectively, which describe the body's response to demands. 'Impairment' highlights the pathological consequence of a prolonged stress response that exceeds the body's adaptive capacity. In the hormonal space, it directly relates to adrenal fatigue and the dysregulation of cortisol and DHEA production.

What is the Mechanism of Stress-Induced Impairment?

Chronic stress leads to sustained activation of the HPA axis, resulting in prolonged high cortisol levels. This hypercortisolism impairs insulin sensitivity, suppresses immune function, and directly inhibits the central release of GnRH and TSH, thereby suppressing the gonadal and thyroid axes. Furthermore, high cortisol levels can reduce neurogenesis in the hippocampus, contributing to cognitive and mood impairment, illustrating a multi-systemic functional decline.

Stress-Induced Impairment ∞ Area

Stress-Induced Impairment

Meaning

A state of measurable physiological or functional decline in a biological system—such as the immune, metabolic, or neuroendocrine systems—resulting directly from chronic or overwhelming psychological or physical stress exposure. This impairment is characterized by a maladaptive response of the hypothalamic-pituitary-adrenal (HPA) axis, leading to sustained allostatic load and subsequent functional breakdown. It is a key factor in the progression of age-related disease.