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Stress-Induced Hormonal Dysregulation

Meaning

Stress-Induced Hormonal Dysregulation is the pathological alteration of the body’s endocrine system resulting from chronic or severe psychological or physiological stress, leading to an imbalance in circulating hormone levels and their signaling pathways. This condition is primarily mediated by the persistent activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis, resulting in prolonged hypercortisolemia and subsequent disruption of the thyroid, gonadal, and growth hormone axes. Clinical manifestations include menstrual irregularities, adrenal fatigue symptoms, and metabolic dysfunction. It is a key factor in chronic wellness issues.