Stress Hormone Mitigation is the clinical strategy focused on reducing the chronic, maladaptive elevation of glucocorticoids, primarily cortisol, and their downstream effects on peripheral tissues. This aims to dampen the persistent sympathetic nervous system overdrive that impairs immune function, glucose metabolism, and reproductive axis signaling. Effective mitigation restores physiological calm.
Origin
This concept arises from stress physiology and endocrinology, where prolonged exposure to high cortisol levels leads to allostatic overload. “Mitigation” implies actively lessening the impact or concentration of these counter-regulatory signals.
Mechanism
Mitigation strategies often involve interventions that support adrenal health, improve receptor sensitivity to cortisol clearance, or directly downregulate CRH/ACTH stimulation via improved sleep and reduced psychological stressors. By normalizing the HPA axis feedback loop, the overall exposure to chronic catabolic signaling is reduced, allowing anabolic processes to resume dominance.
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