What is the Origin of Stress Hormone Attenuation?

This concept arises from psychoneuroendocrinology, focusing on normalizing the chronic activation patterns observed in long-term stress adaptation syndromes. It addresses the dysregulation that occurs after the initial acute response.

What is the Mechanism of Stress Hormone Attenuation?

Attenuation mechanisms focus on enhancing negative feedback sensitivity within the hypothalamus and pituitary, allowing lower cortisol levels to signal system shutdown more effectively. Furthermore, improving peripheral glucocorticoid receptor signaling can ensure that existing cortisol acts efficiently, thus requiring less overall systemic output.

Stress Hormone Attenuation

Meaning

Stress Hormone Attenuation is the clinical goal of moderating the prolonged, elevated activity of the HPA axis mediators, primarily cortisol and catecholamines, in response to chronic psychosocial or physiological stressors. Effective attenuation prevents the sustained catabolic and immunosuppressive effects of chronic stress exposure. We seek to restore HPA axis flexibility.