What is the Origin of Stress Endocrinology Principles?

This term is a formal grouping of established concepts within neuroendocrinology, a field dedicated to the interaction between the nervous and endocrine systems. Principles refer to the universally observed patterns of adaptation and maladaptation to environmental and internal demands, stemming from Selye's General Adaptation Syndrome.

What is the Mechanism of Stress Endocrinology Principles?

The central mechanism involves the hypothalamus releasing Corticotropin-Releasing Hormone (CRH), which stimulates the pituitary to release Adrenocorticotropic Hormone (ACTH), which then prompts the adrenal glands to synthesize and secrete cortisol. These principles emphasize that chronic or dysregulated stress leads to a breakdown of the negative feedback loop, causing prolonged cortisol elevation and subsequent systemic endocrine disruption.

Stress Endocrinology Principles ∞ Area

Stress Endocrinology Principles

Meaning

The fundamental rules and biological laws governing the body’s hormonal response to physiological or psychological stressors, primarily focusing on the activation and regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. These principles dictate the precise release, action, and subsequent feedback control of key stress hormones, most notably cortisol and catecholamines. Understanding these principles is critical for diagnosing and managing stress-induced endocrine dysfunction.