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Stress Buffer

Meaning

A Stress Buffer is a physiological or psychological resource that acts to mitigate the detrimental impact of acute or chronic stressors on the body’s allostatic systems, particularly the Hypothalamic-Pituitary-Adrenal (HPA) axis. In a clinical context, this capacity translates to a more resilient and rapid return to homeostatic balance following a challenge, minimizing the damaging effects of prolonged cortisol exposure. Developing a robust stress buffer is a key objective in hormonal health and longevity optimization.