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Stress Axis Synchronization

Meaning

Stress Axis Synchronization refers to the coordinated, time-locked activation and subsequent deactivation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and its interactions with the sympathetic nervous system. Optimal synchronization ensures a rapid, appropriate release of cortisol and catecholamines in response to a perceived threat, followed by swift negative feedback to restore baseline homeostasis. Dyssynchronization manifests as either a blunted or a chronically exaggerated cortisol response, leading to impaired resilience and metabolic disturbance. This coordination is central to managing allostatic load.