A therapeutic goal focused on reducing the hypersensitivity or hyper-reactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis to perceived stressors, often seen in chronic stress states leading to dysregulated cortisol dynamics. We aim for HPA axis resilience.
Origin
This describes the process of decreasing the sensitivity of the primary endocrine stress response system, the HPA axis, often through sustained regulatory input that promotes allostatic balance.
Mechanism
Desensitization involves normalizing the negative feedback loop, improving glucocorticoid receptor sensitivity in the hypothalamus and pituitary, and lowering baseline allostatic load to prevent excessive or prolonged secretion of cortisol and catecholamines.
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