Stress Axis Damping is the targeted physiological process aimed at normalizing and moderating the activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis, particularly when it exhibits hyperactivity due to chronic psychosocial or physiological stressors. Effective damping prevents the sustained elevation of glucocorticoids that can negatively impact metabolism and immunity. We seek to restore healthy HPA axis rhythmicity.
Origin
This concept originates from stress physiology and endocrinology, focusing on the negative consequences of chronic allostatic overload on the body’s primary stress response system.
Mechanism
The mechanism involves strengthening the negative feedback signaling that returns the HPA axis to baseline after a perceived threat has passed. This can be supported by optimizing adrenal substrate reserves, enhancing vagal tone, or utilizing specific compounds that modulate the sensitivity of CRH or ACTH release mechanisms.
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