Stress Axis Dampening is the clinical intervention aimed at moderating the reactivity and overall setpoint of the Hypothalamic-Pituitary-Adrenal (HPA) axis, particularly in states of chronic physiological stress. We seek to lower the systemic burden of prolonged cortisol exposure. This promotes endocrine balance.
Origin
This concept arises from psychoneuroendocrinology, addressing the pathological consequences of sustained allostatic overload on the body’s primary stress response system. It is a targeted approach to HPA axis normalization.
Mechanism
Dampening is achieved by enhancing the sensitivity of negative feedback receptors in the hippocampus and pituitary, which signal the hypothalamus to reduce CRH release. Supporting nutrient status and optimizing inhibitory neurotransmitter function also contributes to a reduced overall baseline level of adrenal activation.
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