What is the Origin of Stress and Metabolism?

The understanding of this link dates back to the pioneering work of Hans Selye on the General Adaptation Syndrome, which first described the body's systemic response to chronic stressors. The term Stress and Metabolism is a modern clinical pairing that emphasizes the direct, measurable biochemical consequences of psychological load. It bridges the gap between mental health and physical endocrinology.

What is the Mechanism of Stress and Metabolism?

The mechanism is initiated by the release of Corticotropin-Releasing Hormone (CRH) from the hypothalamus, leading to cortisol secretion from the adrenal glands. Cortisol's primary metabolic action is to increase gluconeogenesis and inhibit peripheral glucose uptake, elevating blood sugar to prepare for a perceived threat. Chronically high cortisol also drives the differentiation of pre-adipocytes into mature fat cells, particularly in the abdominal region, creating a vicious cycle of metabolic dysfunction and endocrine resistance.

Stress and Metabolism ∞ Area

Stress and Metabolism

Meaning

Stress and Metabolism describes the profound, interconnected physiological relationship where chronic psychological or physical stress directly alters the body’s energy regulation, nutrient partitioning, and overall metabolic rate. This interaction is mediated primarily by the sustained activation of the hypothalamic-pituitary-adrenal (HPA) axis and the resultant overexposure to cortisol and catecholamines. Over time, this stress-induced metabolic shift promotes visceral fat accumulation, insulin resistance, and a catabolic state, significantly accelerating biological aging and disease risk. Managing stress is therefore a non-negotiable component of metabolic health.