The proactive clinical objective of preserving maximal or near-maximal muscle contractile force generation capabilities, primarily through the sustained optimization of anabolic hormonal signaling and muscle protein synthesis rates. This maintenance strategy counters age-related sarcopenia and preserves functional independence by defending muscle mass and neuromuscular efficiency. It requires consistent endocrine support.
Origin
Rooted in exercise physiology and the study of anabolic resistance, this term defines the goal of preserving muscle quality despite the challenges of aging or catabolic states. Maintenance implies an ongoing effort to counteract the natural decline in muscle fiber density and quality associated with hormonal shifts. It is a key performance indicator in longevity protocols.
Mechanism
The primary mechanism involves ensuring sufficient bioavailable testosterone and growth hormone/IGF-1 signaling to drive muscle protein synthesis rates above degradation rates. Adequate nutrient signaling, particularly sufficient amino acid availability, acts synergistically with these hormones to maximize anabolism. Furthermore, consistent resistance exercise provides the necessary mechanical stimulus to maintain neuromuscular junction integrity and muscle fiber recruitment patterns.
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