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Steroidogenesis Shunting

Meaning

Steroidogenesis shunting refers to the pathological or adaptive diversion of precursor molecules away from their normal pathway toward the synthesis of a different class of steroid hormones within the adrenal glands, gonads, or peripheral tissues. This diversion, or “shunting,” is often caused by enzyme deficiencies, excess substrate availability, or the influence of specific regulatory factors, leading to an overproduction of one hormone class at the expense of another. Clinically, shunting is a critical feature of congenital adrenal hyperplasia and polycystic ovary syndrome, resulting in hormonal imbalances that manifest as significant clinical symptoms. Identifying the specific shunting pattern is key to targeted endocrine intervention.