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Steroidogenesis Impairment

Meaning

Steroidogenesis Impairment refers to any pathological disruption in the complex, multi-step enzymatic cascade responsible for converting cholesterol into biologically active steroid hormones, including cortisol, aldosterone, and sex steroids. This endocrine dysfunction can manifest as a block at various points in the adrenal or gonadal pathways, leading to a deficiency of downstream hormones and a potentially harmful accumulation of upstream precursors. Clinical presentations range from congenital adrenal hyperplasia to acquired forms of hypogonadism. Precise diagnosis of the impairment location is paramount for appropriate hormone replacement and management of associated metabolic and electrolyte imbalances.