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Steroidogenesis Chemistry

Meaning

Steroidogenesis Chemistry is the complex, multi-step biochemical pathway by which cholesterol is enzymatically converted into all the major steroid hormones, including cortisol, aldosterone, testosterone, and the estrogens. This chemical cascade is primarily localized in the adrenal glands and gonads, requiring a precise sequence of hydroxylations and cleavages mediated by cytochrome P450 enzymes. Understanding this chemistry is fundamental for diagnosing and treating hormonal deficiencies or excesses that arise from enzymatic blocks or precursor shortages.