Skip to main content

Steroid Signaling Fidelity

Meaning

Steroid Signaling Fidelity describes the accuracy and efficiency with which steroid hormones, such as testosterone, estrogen, and cortisol, bind to their specific intracellular receptors and successfully execute their intended genetic and metabolic instructions within the target cell. High fidelity implies a clear, robust signal leading to the appropriate physiological response, while compromised fidelity suggests impaired receptor binding or downstream signaling, often seen with age or chronic inflammation. The clinical goal is to maintain this fidelity for optimal hormonal responsiveness and systemic health.