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Steroid Receptor Genes

Meaning

Steroid Receptor Genes encode the specific nuclear proteins that bind lipophilic steroid hormones, such as androgens, estrogens, and glucocorticoids, allowing these hormones to directly influence gene transcription within the cell nucleus. Variations in these genes can dramatically alter an individual’s sensitivity to circulating hormones, even if hormone levels are otherwise normal. These receptors are the ultimate arbiters of steroid action.