What is the Origin of Steroid Receptor?

Rooted in endocrinology, these receptors are classified based on the steroid structure they recognize, such as the Glucocorticoid Receptor (GR) or Androgen Receptor (AR). They represent the fundamental molecular interface between hormones and cellular machinery.

What is the Mechanism of Steroid Receptor?

Upon ligand binding, the receptor typically undergoes a conformational change, dissociates from chaperone proteins, and translocates to the nucleus where it binds to specific DNA sequences known as Hormone Response Elements (HREs). This binding recruits co-activator complexes to initiate target gene transcription, directly controlling the physiological output mediated by that specific steroid hormone.

Steroid Receptor

Meaning

Intracellular proteins, typically located in the cytoplasm or nucleus, that specifically bind lipophilic steroid hormones such as cortisol, testosterone, or estrogen, initiating a cascade of genomic or rapid non-genomic cellular responses. These receptors function as ligand-activated transcription factors, dictating the expression of genes controlling development, metabolism, and reproductive function. Their structure determines the specificity of hormonal action.

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