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Steroid Metabolomics

Meaning

Steroid metabolomics is an advanced analytical approach that involves the comprehensive, high-throughput identification and quantification of the complete set of steroid hormones and their diverse metabolites within a biological sample, such as urine, serum, or saliva. This discipline goes far beyond measuring only parent hormones, providing a detailed map of the entire steroidogenic and catabolic pathways. By simultaneously assessing precursors, active hormones, and downstream metabolites, it offers a functional assessment of enzyme activity and endocrine signaling. Clinically, it is utilized to diagnose complex endocrine disorders, monitor hormone replacement therapy, and assess potential risks associated with differential hormone metabolism.