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Steroid Metabolism Variants

Meaning

Steroid metabolism variants are specific, naturally occurring polymorphisms or mutations within the genes that encode the enzymes and receptors responsible for the synthesis, interconversion, and catabolism of steroid hormones like testosterone, estrogen, and cortisol. These genetic variations can significantly alter the activity of metabolic pathways, leading to inter-individual differences in circulating hormone ratios, receptor sensitivity, and therapeutic response to exogenous hormones. They are key determinants of a patient’s endocrine profile.