What is the Meaning of Steroid Hormones?

Steroid Hormones are a class of lipid-soluble signaling molecules derived from cholesterol, characterized by a common four-ring chemical structure. These hormones, which include androgens, estrogens, progestins, glucocorticoids, and mineralocorticoids, are synthesized primarily by the adrenal glands and gonads. They are critical for regulating a vast array of physiological processes, including stress response, metabolism, inflammation, and sexual differentiation.

What is the Origin of Steroid Hormones?

The chemical structure and biological activity of the major steroid hormones were largely elucidated in the 1930s and 1940s, marking a significant milestone in endocrinology. The term 'steroid' itself is derived from the Greek stereos meaning 'solid' and the suffix -ol for alcohol, referring to their chemical nature. Their discovery provided the foundation for modern hormone replacement therapy.

What is the Mechanism of Steroid Hormones?

Due to their lipid-soluble nature, steroid hormones circulate bound to carrier proteins and readily diffuse across the cell membrane to enter the cytoplasm. They bind to specific intracellular receptors, forming a hormone-receptor complex that translocates to the cell nucleus. This complex then binds to specific DNA sequences, acting as a transcription factor to modulate gene expression, ultimately increasing or decreasing the synthesis of specific proteins to elicit a slow, but profound, physiological effect.

Steroid Hormones ∞ Area ∞ Library 10

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