Steroid Hormone Support is the clinical strategy aimed at ensuring the adequate synthesis, transport, and receptor-mediated action of endogenous steroids such as cortisol, DHEA, testosterone, and estrogens. This support focuses on providing necessary precursors and optimizing the enzymatic pathways required for these critical lipid-soluble signaling molecules. We seek to maintain the physiological balance essential for metabolic regulation and stress adaptation.
Origin
This practice is central to traditional endocrinology and the modern functional approach to hormone replacement and optimization. It signifies a commitment to supporting the entire adrenal and gonadal steroidogenic pathways.
Mechanism
The mechanism involves assessing the entire cascade, starting from cholesterol availability and moving through key enzymes like $17alpha$-hydroxylase and $5alpha$-reductase. Support might include providing substrate precursors, ensuring adequate cofactors for enzymatic conversion, or managing SHBG levels to maintain optimal free hormone fractions. Proper support ensures that these hormones can effectively traverse the cell membrane and engage their nuclear receptors to regulate target gene expression related to energy and immunity.
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