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Steroid Hormone Receptor Sensitivity

Meaning

Steroid Hormone Receptor Sensitivity is the precise measure of a target cell’s responsiveness and efficiency in initiating a downstream biological effect in response to a given circulating concentration of a steroid hormone. This sensitivity is a critical, yet often rate-limiting, determinant of overall hormonal health, as high hormone levels are functionally irrelevant if the corresponding intracellular receptors are downregulated, structurally impaired, or otherwise functionally resistant. Optimizing this receptor sensitivity is a key therapeutic goal for maximizing the biological efficacy of both endogenous and exogenous steroid hormones.