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Steroid Hormone Receptor Density

Meaning

Steroid Hormone Receptor Density refers to the absolute number or concentration of specific protein receptors located within or on the surface of target cells that are capable of binding and initiating a response to circulating steroid hormones like cortisol, estrogen, or testosterone. This density is a critical determinant of tissue sensitivity to hormonal signals, often varying dynamically based on local factors or chronic exposure levels. A high density implies heightened responsiveness to a given hormone concentration, while downregulation suggests a diminished functional output. We must evaluate this parameter to truly understand hormonal efficacy.