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Steady-State Pharmacokinetics

Meaning

Steady-State Pharmacokinetics is a dynamic equilibrium achieved during chronic medication administration where the overall rate at which the drug enters the systemic circulation is precisely balanced by the rate at which the drug is eliminated from the body. This condition results in a plateau of drug concentration in the plasma, which consistently fluctuates within a predictable therapeutic range between doses. Achieving this stable concentration is the primary goal of any long-term dosing regimen, including hormonal therapies, to ensure sustained efficacy and minimize toxicity.