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Steady State

Meaning

In the context of pharmacology and hormonal health, steady state is the dynamic equilibrium achieved when the rate of drug input into the systemic circulation is precisely balanced by the rate of its elimination from the body. During chronic or repeated dosing, the drug concentration in the plasma fluctuates between a maximum and minimum level but remains within a consistent therapeutic range over time. Attaining a stable steady state is the primary clinical goal of most hormone replacement therapies to ensure consistent biological effect and minimize fluctuations in patient well-being.