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Statin Pleiotropic Effects

Meaning

Statin pleiotropic effects refer to the numerous beneficial pharmacological actions of HMG-CoA reductase inhibitors (statins) that extend beyond their primary, intended effect of lowering low-density lipoprotein cholesterol (LDL-C) levels. These secondary effects include anti-inflammatory properties, improved endothelial function, stabilization of atherosclerotic plaques, and immunomodulatory actions. Clinically, these additional benefits contribute significantly to the drug class’s overall reduction in cardiovascular events, independent of their lipid-lowering capability.