The overarching physiological and neurological systems responsible for sensing internal and external environmental cues and then dynamically adjusting the body’s internal milieu, including hormonal output and autonomic balance, to maintain allostasis and promote survival. This mechanism is the fundamental process of regulating the body’s metabolic and emotional “state.”
Origin
This term is a conceptual framework derived from systems biology and neuroendocrinology, recognizing the integrated control loops that govern the entire organism. It emphasizes the active, regulatory role of the central nervous system, particularly the hypothalamus, in coordinating peripheral responses.
Mechanism
The state control mechanism involves continuous sensory input to the central nervous system, which integrates this information to determine the appropriate hormonal and autonomic output. For example, a perceived threat triggers the hypothalamic-pituitary-adrenal (HPA) axis to release cortisol and the sympathetic nervous system to release catecholamines, shifting the body into a high-alert, catabolic state. Conversely, safety and nutrient abundance shift the control towards parasympathetic dominance and anabolic hormone release.
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