What is the Origin of SSRIs for PMDD?

The term is an acronym for Selective Serotonin Reuptake Inhibitors, a class of antidepressant drugs developed in the late 20th century, combined with the abbreviation for Premenstrual Dysphoric Disorder. The therapeutic application for PMDD originated from the observation that the disorder shares neurobiological features with major depressive disorder, coupled with the discovery of the rapid onset of action of these drugs when administered during the symptomatic luteal phase.

What is the Mechanism of SSRIs for PMDD?

The mechanism of action is thought to extend beyond their classic role of increasing synaptic serotonin levels, operating instead through a rapid modulation of neuroactive steroids. SSRIs appear to quickly restore sensitivity to the GABA-A receptor, which is hypothesized to be dysregulated in PMDD due to the precipitous drop in progesterone and its metabolite, allopregnanolone, during the late luteal phase. This rapid neurochemical effect, distinct from their antidepressant action, quickly stabilizes the central nervous system's response to the natural hormonal fluctuations.

SSRIs for PMDD ∞ Area

SSRIs for PMDD

Meaning

SSRIs for PMDD refers to the use of Selective Serotonin Reuptake Inhibitors as a first-line pharmacological treatment for Premenstrual Dysphoric Disorder, a severe and disabling cyclical mood disorder. These agents, which include fluoxetine and sertraline, are typically administered either continuously throughout the menstrual cycle or intermittently during the late luteal phase when symptoms emerge. Their efficacy lies in rapidly ameliorating the intense emotional and physical symptoms associated with PMDD.