What is the Origin of SSRIs?

The term is a descriptive pharmacological abbreviation, reflecting the drug class's highly selective action on the serotonin reuptake mechanism. The development of SSRIs represented a major advance over older antidepressants due to their improved side-effect profile.

What is the Mechanism of SSRIs?

The primary mechanism of action involves the SSRI molecule binding to and inhibiting the serotonin transporter (SERT) protein located on the presynaptic neuronal membrane. This inhibition prevents the reabsorption of serotonin back into the presynaptic neuron, consequently increasing the concentration and duration of serotonin's action in the synapse. This enhanced serotonergic signaling is thought to alleviate depressive symptoms, although it can also interfere with hormonal regulation of sexual response and contribute to common side effects like reduced libido.

SSRIs

Meaning

SSRIs, an acronym for Selective Serotonin Reuptake Inhibitors, are a class of psychotropic medications widely prescribed to treat major depressive disorder, anxiety disorders, and certain other psychiatric conditions. These agents function by specifically increasing the concentration of the neurotransmitter serotonin in the synaptic clefts of the brain. Their use is clinically relevant to hormonal health due to the significant overlap and bidirectional interaction between the serotonin system and the endocrine axes, which can influence mood, sexual function, and appetite.