What is the Origin of SS-31 Peptide Research?

The peptide was originally developed by researchers, notably Dr. Hazel Szeto at Weill Cornell Medical College, as part of a targeted approach to creating cell-penetrating antioxidants. Its designation, SS-31, is derived from its sequence of amino acids and its early research code. The work is rooted in the emerging field of mitochondrial medicine, recognizing mitochondrial dysfunction as a central factor in aging and chronic disease.

What is the Mechanism of SS-31 Peptide Research?

The primary mechanism of SS-31 involves its accumulation within the negatively charged inner mitochondrial membrane where it specifically binds to cardiolipin, a critical phospholipid. By interacting with cardiolipin, the peptide helps to stabilize the structure of the electron transport chain's supercomplexes, which improves the efficiency of oxidative phosphorylation and significantly reduces the pathological production of reactive oxygen species (ROS).

SS-31 Peptide Research ∞ Area

SS-31 Peptide Research

Meaning

SS-31 Peptide Research refers to the scientific investigation of Elamipretide, a synthetic tetrapeptide that has demonstrated a unique and highly selective affinity for the inner mitochondrial membrane. This molecule is a focus in longevity and disease research due to its potential role in mitigating cellular dysfunction. It is primarily studied for its capacity to restore mitochondrial integrity and enhance cellular bioenergetics.