What is the Origin of SS-31 Cardioprotection?

This term originates from advanced peptide research and specialized cardiovascular medicine, specifically focusing on the drug candidate SS-31, also known as Elamipretide. The 'Cardioprotection' refers to the clinically observed, measurable benefit of preserving myocardial function and viability following injury. The underlying system is the intricate mitochondrial network within cardiomyocytes, the primary heart muscle cells.

What is the Mechanism of SS-31 Cardioprotection?

SS-31 directly and rapidly binds to cardiolipin, a unique phospholipid found only in the inner mitochondrial membrane, thereby stabilizing the membrane structure and preventing the release of pro-apoptotic factors. By preserving the structural and functional integrity of the electron transport chain, it significantly reduces the production of damaging reactive oxygen species and maintains the efficiency of ATP synthesis. This action prevents critical cellular energy deficits and subsequent cardiomyocyte death following an ischemic event.

SS-31 Cardioprotection ∞ Area

SS-31 Cardioprotection

Meaning

The therapeutic action of the synthetic, mitochondrial-targeting tetrapeptide SS-31 (Elamipretide) to selectively shield the heart muscle and overall cardiovascular system from damage, particularly that caused by ischemia-reperfusion injury and excessive oxidative stress. This protective and restorative effect is mediated by the peptide’s unique ability to selectively concentrate in the inner mitochondrial membrane and preserve critical mitochondrial functional integrity. It represents a highly targeted strategy for enhancing cardiac cellular bioenergetics.