What is the Meaning of SS-31?

A synthetic, small peptide, often referred to by its chemical name elamipretide, that selectively targets the inner mitochondrial membrane. This compound is under investigation for its potential to protect and restore mitochondrial function, which is a critical determinant of cellular energy production and overall metabolic health. It is a novel therapeutic agent in the longevity space.

What is the Origin of SS-31?

The peptide was developed based on research into the structure and function of mitochondria, the cellular organelles responsible for oxidative phosphorylation. Its designation, SS-31, refers to its specific sequence and its initial development in the laboratory of Dr. Hazel S. Szeto. The development represents a targeted approach to mitochondrial medicine.

What is the Mechanism of SS-31?

SS-31 operates by concentrating in the inner mitochondrial membrane, where it interacts with cardiolipin, a phospholipid essential for mitochondrial structure and bioenergetics. This interaction protects cardiolipin from oxidative damage and preserves the integrity of the electron transport chain, thereby enhancing ATP synthesis and reducing the production of reactive oxygen species. This mechanism directly supports the cellular powerhouses.

SS-31 ∞ Area

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