What is the Origin of SRD5A2 Gene?

The name is an acronym for 'Steroid 5-alpha Reductase, Alpha Polypeptide 2,' directly reflecting the enzyme's function and chemical class. The discovery of this gene and its role was foundational to understanding the molecular basis of male sexual development and certain androgen-dependent conditions. Its origin is rooted in molecular genetics and reproductive endocrinology.

What is the Mechanism of SRD5A2 Gene?

The enzyme encoded by the SRD5A2 gene catalyzes the reduction of the double bond between carbons 4 and 5 in the steroid ring of testosterone, transforming it into dihydrotestosterone (DHT). DHT is a significantly more potent androgen that binds to the androgen receptor with greater affinity and stability than testosterone itself. Variations or mutations in this gene can therefore lead to conditions ranging from ambiguous genitalia to increased risk of benign prostatic hyperplasia.

SRD5A2 Gene ∞ Area

SRD5A2 Gene

Meaning

The SRD5A2 gene provides the genetic blueprint for producing the enzyme steroid 5-alpha reductase type 2, a key enzyme in androgen metabolism. This enzyme is primarily expressed in androgen-sensitive tissues, including the prostate, seminal vesicles, and hair follicles. The gene’s activity is clinically significant because it determines the rate at which the less potent testosterone is converted into the highly potent dihydrotestosterone (DHT).

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Can Genetic Analysis Reliably Predict Finasteride Response in All Individuals?

Genetic analysis of the androgen receptor offers a strong probabilistic guide for finasteride's effect on hair, yet a full response profile depends on a wider neuroendocrine context.

∞ CAG Repeats
∞ Pharmacogenomics
∞ SRD5A2 Gene

HRTioJuly 26, 2025