What is the Origin of SRD5A Reductase?

The term originates from the systematic nomenclature for the gene family, SRD5A, which encodes the steroid 5-alpha reductase enzymes. Its biological significance was established through the study of congenital deficiencies, where mutations in the gene lead to incomplete male sexual differentiation. The discovery of its role in prostate physiology led to the development of specific inhibitors that target its activity.

What is the Mechanism of SRD5A Reductase?

The enzymatic mechanism involves the transfer of a hydride ion from the cofactor NADPH to the Δ4-double bond of the steroid substrate, leading to the reduction at the C5 position. The SRD5A family has three main isoforms (Type 1, 2, and 3), each encoded

SRD5A Reductase ∞ Area

SRD5A Reductase

Meaning

SRD5A Reductase refers to a family of integral membrane enzymes, specifically the 5-alpha reductases, which catalyze the irreversible conversion of various 3-oxo-Δ4-steroids, most notably testosterone, into their corresponding 5-alpha-reduced metabolites. The most clinically significant reaction is the conversion of testosterone into the highly potent androgen, dihydrotestosterone (DHT). These enzymes are crucial mediators of androgen action in target tissues and are essential for male sexual development and the regulation of androgen-sensitive tissues like the prostate and hair follicles. Pharmacological inhibition of this enzyme is a common strategy in treating androgen-related conditions.