What is the Origin of Spironolactone for Hirsutism?

Spironolactone was originally developed as a diuretic, but its secondary anti-androgenic properties were recognized through clinical observation of its effects on mineralocorticoid and androgen receptors. The term describes its targeted application to the specific clinical manifestation of hirsutism, which is a hallmark of hyperandrogenism. This therapeutic approach addresses a core symptom of endocrine imbalance.

What is the Mechanism of Spironolactone for Hirsutism?

Spironolactone functions as a competitive antagonist of the androgen receptor, physically blocking androgens like testosterone and dihydrotestosterone (DHT) from binding to their target sites in the hair follicle and sebaceous glands. Furthermore, it may also inhibit certain androgen-producing enzymes. This dual mechanism effectively reduces the androgenic stimulation of hair growth, leading to a measurable reduction in hair density and coarseness over several months of consistent treatment.

Spironolactone for Hirsutism ∞ Area

Spironolactone for Hirsutism

Meaning

Spironolactone for Hirsutism refers to the off-label clinical use of the potassium-sparing diuretic spironolactone as an anti-androgen agent to treat hirsutism, which is the excessive growth of coarse body hair in women, often due to Polycystic Ovary Syndrome (PCOS). This therapy is employed to mitigate the cosmetic and psychological impact of androgen excess by blocking the action of male hormones at the hair follicle. It is a common, effective strategy in dermatologic endocrinology.