Question 1

What is the Meaning of Spironolactone for Hirsutism?

Accepted Answer

Spironolactone for hirsutism involves therapeutic use of spironolactone, a synthetic steroid, to reduce excessive terminal hair growth in androgen-sensitive body areas in individuals assigned female. Hirsutism, coarse, dark hair in male-like patterns, typically stems from hyperandrogenism. This intervention alleviates cosmetic and psychological burden.

Question 2

What is the Context of Spironolactone for Hirsutism?

Accepted Answer

Within the endocrine system, spironolactone acts as an anti-androgen, addressing hirsutism from elevated androgen levels or increased tissue sensitivity. Polycystic Ovary Syndrome (PCOS) frequently underlies androgen excess. Spironolactone modulates androgen actions at the cellular level, addressing hair overgrowth.

Question 3

What is the Significance of Spironolactone for Hirsutism?

Accepted Answer

Clinical importance of spironolactone in managing hirsutism lies in its capacity to mitigate a distressing physical symptom impacting patient self-perception and quality of life. Reducing unwanted hair, this treatment offers tangible improvement in appearance and psychological comfort. It represents a key pharmacological strategy for long-term management of androgen-related dermatological manifestations.

Question 4

What is the Mechanism of Spironolactone for Hirsutism?

Accepted Answer

Spironolactone exerts anti-androgenic effects through multiple pathways. It competitively blocks androgen receptors in target tissues like hair follicles, preventing androgen binding and stimulation. It inhibits 5-alpha-reductase, converting testosterone to more potent dihydrotestosterone. Spironolactone also increases hepatic synthesis of sex hormone-binding globulin (SHBG), binding free testosterone, reducing its bioavailability.

Question 5

What is the Application of Spironolactone for Hirsutism?

Accepted Answer

Spironolactone is administered orally, with daily doses adjusted based on individual response. Due to the slow hair growth cycle, a noticeable therapeutic effect typically requires six to twelve months of consistent use. It is often prescribed alongside oral contraceptive pills, offering complementary androgen suppression and menstrual regulation. Regular clinical monitoring is crucial.

Question 6

What is the Metric of Spironolactone for Hirsutism?

Accepted Answer

Efficacy of spironolactone for hirsutism is primarily evaluated through objective clinical assessment using standardized scoring systems, like the modified Ferriman-Gallwey score. Patient self-report of symptom improvement also provides valuable data. Serum potassium levels are routinely monitored due to the medication's potassium-sparing diuretic properties, mitigating hyperkalemia risk. Blood pressure assessment is standard.

Question 7

What is the Risk of Spironolactone for Hirsutism?

Accepted Answer

Spironolactone carries specific risks. Hyperkalemia is a significant concern, especially for patients with renal impairment or those on other potassium-sparing agents. Common effects include menstrual irregularities, breast tenderness, gastrointestinal upset, and dizziness. Given its teratogenic potential, strict adherence to effective contraception is mandatory for all women of reproductive age during treatment.

Spironolactone for Hirsutism

Meaning

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Mechanism

Application

Metric

Risk

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