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Specialized Pro-Resolving Mediators

Meaning

A class of endogenous lipid molecules, including resolvins, protectins, and maresins, derived from omega-3 fatty acids, which actively orchestrate the termination phase of the acute inflammatory response. Unlike traditional anti-inflammatory agents that merely suppress the inflammatory process, these mediators promote the efficient clearance of inflammatory debris and the active restoration of tissue homeostasis. Their discovery highlights a proactive, self-limiting mechanism in the body’s response to injury and infection.