Specific sequences of amino acids, often oligopeptides or polypeptides, that possess distinct biological activities beyond their role as protein building blocks, acting instead as signaling molecules, secretagogues, or selective receptor modulators. These chains are essential for targeted physiological communication.
Origin
This term combines the basic biological unit of amino acid chains (peptides or proteins) with the qualifier specialized, reflecting the modern clinical focus on the functional, non-nutritional roles of these molecules, which is a key area of peptide therapy. It draws from molecular biology and pharmaceutical chemistry.
Mechanism
These chains function by exhibiting high specificity for certain cell surface receptors, mimicking or blocking the action of larger, endogenous hormones or neurotransmitters. For example, certain chains can stimulate the pulsatile release of growth hormone from the pituitary gland or selectively modulate cytokine activity. Their precise structure dictates their function, allowing for targeted modulation of metabolic, inflammatory, or regenerative pathways with minimal off-target effects.
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