Somatropin Analogs are synthetic, modified versions of the naturally occurring human growth hormone (hGH), Somatropin, designed to mimic or enhance its biological actions. These pharmaceutical agents are engineered to possess similar or improved pharmacodynamic properties, often featuring a longer half-life or enhanced receptor binding affinity. Clinically, these analogs are used to treat growth hormone deficiency in both children and adults, promoting growth, metabolism, and body composition improvements.
Origin
The term combines ‘Somatropin,’ the generic name for recombinant human growth hormone, with ‘analogs,’ indicating a compound that is structurally similar to another but differs slightly in chemical composition. The development of these analogs stemmed from efforts in pharmaceutical biotechnology to create more convenient and effective dosing regimens, particularly by extending the duration of action. This engineering feat allows for less frequent injections while maintaining therapeutic efficacy.
Mechanism
Somatropin analogs bind to the growth hormone receptors on target cells, primarily in the liver, stimulating the production of Insulin-like Growth Factor 1 (IGF-1). IGF-1 then mediates most of the growth-promoting and metabolic effects of the hormone, including protein synthesis, lipolysis
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