Somatotropin Axis

Meaning

The Somatotropin Axis, also widely known as the Growth Hormone (GH) axis, is a critical neuroendocrine regulatory system comprising the hypothalamic hormones, pituitary somatotroph cells, and the peripheral hormone Insulin-like Growth Factor 1 (IGF-1). This axis primarily governs somatic growth, cellular proliferation, and metabolic regulation throughout the lifespan. Clinical assessment of this axis is essential for accurately diagnosing and managing growth disorders, as well as understanding its profound role in metabolic health and the aging process.

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Growth hormone peptides stimulate endogenous GH release, optimizing mitochondrial function and metabolic fuel utilization for cellular energy.

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