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Somatotropic Signaling Pathways

Meaning

Somatotropic Signaling Pathways encompass the complex cascade of molecular events initiated by the binding of Growth Hormone (GH) to its receptor on target cells, leading to cellular growth, metabolism, and proliferation. This pathway primarily involves the downstream release of Insulin-like Growth Factor 1 (IGF-1) from the liver, which then acts on its own receptors to mediate many of GH’s anabolic and metabolic effects. Maintaining balanced activity within this axis is crucial for muscle and bone maintenance, metabolic regulation, and overall tissue repair throughout the lifespan. Dysregulation can lead to conditions like gigantism or growth hormone deficiency.