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Somatotropic Signaling Attenuation

Meaning

Somatotropic Signaling Attenuation refers to the age-related or pathological reduction in the intensity and effectiveness of the signaling cascade initiated by Growth Hormone (GH) and its downstream mediator, Insulin-like Growth Factor 1 (IGF-1). This attenuation results in diminished anabolic drive, impaired tissue repair, reduced lean body mass, and altered metabolic function, collectively contributing to the syndrome of somatopause. Clinically, this decline is a significant factor in sarcopenia and changes in body composition associated with aging. The goal of restorative therapies is often to counteract this attenuation and restore youthful GH/IGF-1 axis function.