Skip to main content

Somatotropic Response Fidelity

Meaning

Somatotropic response fidelity refers to the precision and consistency with which target tissues, particularly the liver, muscle, and adipose tissue, respond to the pulsatile signaling of Growth Hormone (GH). High fidelity implies that a given GH pulse reliably elicits the expected downstream biological effects, such as the production of Insulin-like Growth Factor 1 (IGF-1) and the mobilization of fatty acids. Reduced fidelity, often seen with aging or chronic inflammation, signifies a state of GH resistance, where the tissue response is blunted despite adequate GH levels.