Somatotropic axis tuning refers to the dynamic adjustment of the signaling strength and sensitivity within the Growth Hormone (GH) axis, involving the hypothalamus, pituitary, and target tissues.
Origin
This term emerges from modern endocrinology, emphasizing the plasticity and modulation of the GH-IGF-1 axis rather than static set points.
Mechanism
Tuning is accomplished via numerous factors, including nutrient status, sleep quality, and counter-regulatory hormones like cortisol, which modulate GH pulse amplitude and receptor responsiveness in peripheral tissues like adipose and muscle.
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