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Somatotropic Axis Interplay

Meaning

Somatotropic Axis Interplay describes the complex, reciprocal communication and regulatory feedback loops within the neuroendocrine system involving Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1). This axis is central to somatic growth, metabolic regulation, and cellular repair throughout the lifespan. Optimal interplay is characterized by the pulsatile release of GH from the pituitary, which stimulates IGF-1 production primarily in the liver, leading to anabolic and regenerative effects on muscle, bone, and connective tissue. Dysfunction in this axis is a significant marker of age-related decline and frailty.