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Somatotropic Axis Activity

Meaning

Somatotropic Axis Activity refers to the functional status and output of the Hypothalamic-Pituitary-Liver axis, the primary endocrine system responsible for regulating somatic growth, cellular regeneration, and metabolic homeostasis throughout life. This activity is measured by the dynamic interplay of Growth Hormone-Releasing Hormone (GHRH), Growth Hormone (GH), and Insulin-like Growth Factor 1 (IGF-1). Optimal activity of this axis is fundamental to maintaining the Anabolic Platform, preserving lean body mass, supporting bone density, and ensuring efficient fat metabolism. A decline in this activity is clinically recognized as Somatopause.